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Researchers Discover a Treatment for Man’s Mysterious Orgasm Allergy

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Most of the articles about men and orgasms have to do with containing them – warding off the big O to prolong the pleasure or so that their partners can reach their climax first.

A 25-year-old man avoided her for a completely different and unfortunate reason: According to a recent study, he was allergic to his own orgasms.


"He feared ejaculation," researchers wrote in Urology Case Reports. This would create a flood of symptoms: low energy, weakness, mental fog and difficulty finding the right word. Talk about stunning sex – the wrong way.

The poor guy started experiencing the disease at the age of 16 when he noticed that masturbation or sex triggered these ailments. "The onset of symptoms can occur immediately or be delayed by 2-3 days and takes 1-2 weeks," the researchers wrote. As a result, the unnamed man avoided social interactions when the symptoms appeared. Of course, this affected his work and school life.

What this man had was post-orgasmic disease syndrome, or POIS. It is rare and difficult to treat. We have only known POIS since 2002, when it was discovered by Marcel D. Waldinger and his team.

Waldinger defined it as more than an allergy: it is a systemic autoimmune response to seminal plasma or semen. He also noted the lack of POIS knowledge among many doctors, which could result in many symptoms being dismissed as psychological rather than physical, and their patients referred to a psychologist for treatment.


However, the condition and its symptoms are very physical and can include flu-like illnesses. Depression; irritated, burning eyes with blurred vision; dry mouth and muscle weakness or pain. They often occur within half an hour after orgasm. As POIS discoverer Waldinger found, many of his 45 subjects avoided sex and masturbation and accepted a chaste life. He tried to inject volunteers with diluted samples of their own semen for treatment, but this did not work.


The research subject has previously tried many drugs, including diet, antihistamines, supplements, and niacin. They didn't work either.

They found that the culprit was a lack of testosterone. HCG injections, known as the "pregnancy hormone" but also helping men to increase testosterone production, showed an increase in total testosterone three times a week over a period of six weeks.

And his symptoms decreased significantly. He was able to orgasm without complaints. He was happy and could masturbate regularly – and chase sex that was explosive but didn't blow his life up.

"It is important that he is no longer afraid of sexual activities," the researchers concluded.

We call this a happy ending.



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