(as of Aug 04,2021 16:46:56 UTC – Details)
The effect of androgenic anabolic steroids (dianabol, oral turinabol), testosterone-propionate and physical exercise on the cardiac myocyte hypertrophy, capillary supply and angiogenesis of the heart.
The present book (thesis) shows, for the first time, that various anabolic steroids (dianabol, oral turinabol) as well as testosterone propionate, combined with physical exercise, impair the exercise-induced new capillary growth (angiogenesis). Moreover they induce a mild cardiac myocyte hypertrophy. These alterations may lead to impaired oxygen supply to the heart muscle, especially in connection with physical exercise.
The book is of interest for numerous biomedical fields including internal medicine, cardiology, sports medicine, exercise physiology, pharmacology and tumour research as well as for sports and anti-doping measures.
The findings from this project have high clinical interest as a hypertrophy of the cardiac muscle cells occurs in connection with a reduction of the capillarization during physical exercise. The consequence may be a disproportion between the oxygen demand and the oxygen supply, which can trigger an infarct.
The findings have great practical importance both for medical knowledge and antidoping measures. The World Federation of Sports Medicine (FIMS) of 128 nations awarded Tagarakis and his colleagues for this contribution at the World Congress of Sports Medicine in Athens, Greece (1994) with first place.
Univ.-Prof. mult. Dr. med. Dr. h. c. mult. Wildor Hollmann